gene

EPHB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPHB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

3Outgoing

3Incoming

0Experiments

0Debates

Summary

EPHB2 (Eph Receptor B2) is a member of the Eph receptor tyrosine kinase family involved in synaptic plasticity, memory formation, and neurodegenerative disease pathogenesis.

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🧬 Gene Info

Gene Symbol	EPHB2
Full Name	Eph Receptor B2
Chromosome	1p36.12
Protein Type	Receptor
Function	is a member of the Eph receptor tyrosine kinase family that plays crucial roles in neural development, synaptic plasticity, and cellular communication within the central nervous system.
Primary Expression	the developing nervous system, where it plays critical roles in neuronal migration, axon guidance, and target selection
Molecular Weight	110 kDa
UniProt ID	P29323
Ensembl ID	ENSG00000199639
GeneCards	EPHB2
Human Protein Atlas	EPHB2
Associated Diseases	Alzheimer's disease, Parkinson's disease, deafness
Interactions	EPHA5, FBXO45, MYC, UBIQUITIN
KG Connections	6 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: EPHB2 — AlphaFold P29323 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

EPHB2 Gene

gene · 2330 words

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Pathway Diagram

graph TD
    EPHB2["EPHB2"]
    Als{"Als"}
    EPHB2 -->|"interacts with"| Als
    Ms{"Ms"}
    EPHB2 -->|"interacts with"| Ms
    UBIQUITIN["UBIQUITIN"]
    EPHB2 -->|"activates"| UBIQUITIN
    neurodegeneration["neurodegeneration"]
    EPHB2 -->|"implicated in"| neurodegeneration
    EPHA5["EPHA5"]
    EPHA5 -->|"phosphorylates"| EPHB2
    FBXO45["FBXO45"]
    FBXO45 -->|"interacts with"| EPHB2
    MYC["MYC"]
    MYC -->|"interacts with"| EPHB2
    style EPHB2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (3)

Target	Relation	Type	Str
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
UBIQUITIN	activates	gene	0.60

Incoming (3)

Source	Relation	Type	Str
EPHA5	phosphorylates	gene	0.90
FBXO45	interacts_with	gene	0.60
MYC	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EPHB2 in their description or question text

No additional research found