gene

DUSP9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DUSP9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

0Hypotheses

0Analyses

8Outgoing

1Incoming

0Experiments

0Debates

Summary

DUSP9 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, implicated in. Associated with Cancer, Tumor. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	Dual Specificity Phosphatase 9
Chromosome	Xq28
Protein Type	Phosphatase
Function	DUSP9 encodes MKP-4, a dual-specificity phosphatase belonging to the family of MAPK phosphatases (MKPs).
Primary Expression	placental and embryonic tissues
Amino Acids	170 aa
Pathways	MAPK signaling, MAPK
UniProt ID	Q99956
NCBI Gene ID	1852
Ensembl ID	ENSG00000138617
OMIM	300480
p38 MAPK	Involved in stress responses and inflammation
High Expression	Placenta, embryonic tissues
Moderate Expression	Brain (specific regions), liver, adipose tissue
Low/Detectable	Most other adult tissues
Associated Diseases	neurodegeneration
Interactions	ERK, FOXO3, HIF1, KLF4, P38
KG Connections	9 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DUSP9 — AlphaFold Q99956 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DUSP9 Gene

gene · 926 words

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Pathway Diagram

graph TD
    DUSP9["DUSP9"]
    Cancer{"Cancer"}
    DUSP9 -->|"regulates"| Cancer
    Tumor{"Tumor"}
    DUSP9 -->|"activates"| Tumor
    FOXO3["FOXO3"]
    DUSP9 -->|"activates"| FOXO3
    HIF1["HIF1"]
    DUSP9 -->|"activates"| HIF1
    KLF4["KLF4"]
    DUSP9 -->|"activates"| KLF4
    CANCER["CANCER"]
    DUSP9 -->|"regulates"| CANCER
    P38["P38"]
    DUSP9 -->|"activates"| P38
    Mapk(["Mapk"])
    DUSP9 -->|"activates"| Mapk
    neurodegeneration["neurodegeneration"]
    DUSP9 -->|"implicated in"| neurodegeneration
    ERK["ERK"]
    ERK -->|"activates"| DUSP9
    style DUSP9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
Tumor	activates	disease	0.65
Cancer	regulates	disease	0.65
P38	activates	gene	0.60
HIF1	activates	gene	0.60
CANCER	regulates	gene	0.60
FOXO3	activates	gene	0.60
Mapk	activates	pathway	0.60
KLF4	activates	gene	0.60

Incoming (1)

Source	Relation	Type	Str
ERK	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DUSP9 in their description or question text

No additional research found