gene

DRD3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DRD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

5Outgoing

5Incoming

0Experiments

0Debates

Summary

Page for DRD3 — Dopamine Receptor D3

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🧬 Gene Info

Gene Symbol	DRD3
Full Name	Dopamine Receptor D3
Chromosome	3q13.31
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the limbic system and plays critical roles in reward, motivation, and movement control
Molecular Weight	130 kDa
Pathways	MAPK, PI3K
UniProt ID	P35462
NCBI Gene ID	1818
Ensembl ID	ENSG00000151577
OMIM	139251
GeneCards	DRD3
Human Protein Atlas	DRD3
Associated Diseases	neurodegeneration
Known Drugs/Compounds	D-520
Interactions	AMPK, DRD2, ULK1
KG Connections	10 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DRD3 — AlphaFold P35462 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DRD3 Gene

gene · 989 words

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DRD3 — Dopamine Receptor D3

gene · 525 words

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Pathway Diagram

graph TD
    DRD3["DRD3"]
    Berberine_Inspired_Ionizable_Lipid["Berberine-Inspired Ionizable Lipid"]
    Blood_Brain_Barrier_Penetration["Blood-Brain Barrier Penetration"]
    D_520{"D-520"}
    neurodegeneration["neurodegeneration"]

    DRD3 -->|"mediates"| Berberine_Inspired_Ionizable_Lipid
    DRD3 -->|"mediates"| Blood_Brain_Barrier_Penetration
    D_520 -->|"activates"| DRD3
    DRD3 -->|"implicated in"| neurodegeneration

    style DRD3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Berberine_Inspired_Ionizable_Lipid fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff
    style Blood_Brain_Barrier_Penetration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff
    style D_520 fill:#1a3a3a,stroke:#4dd0e1,stroke-width:2px,color:#fff
    style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff

Outgoing (5)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:DRD3	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
autophagy pathway	participates_in	pathway	0.60
ULK1	activates	gene	0.60
neurons	expressed_in	cell_type	0.55

Incoming (5)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:DRD3	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
D-520	binds	drug	0.90
AMPK	activates	gene	0.60
DRD2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DRD3 in their description or question text

No additional research found