gene

CREB5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CREB5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

14Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for CREB5 — cAMP Responsive Element Binding Protein 5

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🧬 Gene Info

Gene Symbol	CREB5
Full Name	cAMP Responsive Element Binding Protein 5
Chromosome	7p15.1
Protein Type	Gene
Function	Like other CREB family members, CREB5 contains a basic leucine zipper (bZIP) domain that facilitates DNA binding and protein dimerization 5.
Primary Expression	brain regions involved in learning and memory
Pathways	Angiogenesis, Dna Methylation, Epigenetic
GeneCards	CREB5
Human Protein Atlas	CREB5
Phosphorylation	CREB5 can be phosphorylated at various residues, affecting its transcriptional activity
Protein-protein interactions	CREB5 interacts with other transcription factors and coactivators
Cellular signaling pathways	Multiple signaling cascades converge on CREB5 to modulate its function
Neuronal survival	CREB-mediated transcription promotes expression of anti-apoptotic genes
Synaptic plasticity	CREB regulates genes involved in long-term potentiation (LTP) and memory formation
Associated Diseases	Common Diseases, Complex Human Diseases
Interactions	FOXO3, MYH7
KG Connections	15 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CREB5 — cAMP Responsive Element Binding Protein 5

gene · 1281 words

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CREB5 Protein — cAMP Responsive Element Binding Protein 5

protein · 593 words

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Pathway Diagram

graph TD
    CREB5["CREB5"]
    Als{"Als"}
    CREB5 -->|"regulates"| Als
    Ms{"Ms"}
    CREB5 -->|"regulates"| Ms
    MYH7["MYH7"]
    CREB5 -->|"activates"| MYH7
    FOXO3["FOXO3"]
    CREB5 -->|"activates"| FOXO3
    EXERCISE["EXERCISE"]
    CREB5 -->|"regulates"| EXERCISE
    Epigenetic(["Epigenetic"])
    CREB5 -->|"regulates"| Epigenetic
    Dna_Methylation(["Dna Methylation"])
    CREB5 -->|"regulates"| Dna_Methylation
    Angiogenesis(["Angiogenesis"])
    CREB5 -->|"regulates"| Angiogenesis
    neurodegeneration["neurodegeneration"]
    CREB5 -->|"implicated in"| neurodegeneration
    style CREB5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (14)

Target	Relation	Type	Str
Cell Types	expressed_in	cell_type	0.80
Complex Human Diseases	associated_with	disease	0.70
Common Diseases	associated_with	disease	0.70
Muscle Fibers	expressed_in	cell_type	0.70
Plasma Proteome	associated_with	biological_process	0.70
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
FOXO3	activates	gene	0.60
Epigenetic	regulates	pathway	0.60
Dna Methylation	regulates	pathway	0.60
Angiogenesis	regulates	pathway	0.60
MYH7	activates	gene	0.60
EXERCISE	regulates	gene	0.60
Cardiac Repolarization	participates_in	biological_process	0.60

Incoming (1)

Source	Relation	Type	Str
genes-creb5	linked_to	wiki_page	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CREB5 in their description or question text

No additional research found