Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CIRCADIAN_RHYTHM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| HDAC3 | regulated_by | gene | 0.80 |
| LIVER_INJURY | regulates | disease | 0.72 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Circadian Rhythm Entrainment of Reactive Astrocytes | 0.722 | neurodegeneration | Astrocyte reactivity subtypes in neurode |
| Circadian Rhythm Amplification to Restore Network Oscillatio | 0.360 | connectomics | Human connectome alterations in Alzheime |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-11 | 0 hypotheses
spatial memory | 2026-04-08 | 0 hypotheses
neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.710
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Circadian gene expression effects of SD vs ketamine | exploratory | depression | 0.950 | 0.00 | C57BL/6J mice | proposed | N/A |
| CLOCK/BMAL1 regulation of ICC autophagy in GERD model | exploratory | gastroesophageal reflux diseas | 0.900 | 0.00 | primary esophageal interstitia | proposed | N/A |
| Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Brainstem Circuit Modulation for PSP | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Non-Dopaminergic Neurotransmitter Degeneration in PD - Experiment Desi | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury. [PMID:40269168] | Ruan W, Li T, Bang IH, Lee J, Deng W, Ma | Nature | 2025 | 1 |
| Obstructive sleep apnea syndrome, orexin, and sleep-wake cycle: The link with th [PMID:39864923] | Fernandes M, Liguori C | Handb Clin Neurol | 2025 | 1 |
| Circadian Influences on Brain Lipid Metabolism and Neurodegenerative Diseases. [PMID:39728504] | Hussain Y, Dar MI, Pan X | Metabolites | 2024 | 1 |
| Circadian rhythm regulates the function of immune cells and participates in the [PMID:38678017] | Zeng Y, Guo Z, Wu M, Chen F, Chen L | Cell Death Discov | 2024 | 1 |
| Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases. [PMID:32705594] | Pan X, Mota S, Zhang B | Adv Exp Med Biol | 2020 | 1 |
| BMAL1 attenuates myocardial infarction-induced fibrosis via suppressing p-SMAD3/ [PMID:41909150] | Zhang D, Wang H, Gu Z, Zhang L, Hu Z, Wa | Biochemistry and biophysics re | 2026 | 0 |
| Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses [PMID:41092646] | Lin L, Liang X, Xu Z, Li Y, Guo Z et al. | Biomaterials | 2026 | 0 |
| The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mit [PMID:41486525] | Sica V, Sato T, Tsialtas I, Hernandez S, | J Biol Rhythms | 2026 | 0 |
| Glycaemic, appetite and circadian benefits of a dairy-enriched diet with high-pr [PMID:41578008] | Tsameret S, Froy O, Matz Y, Landau Z, Tw | Diabetologia | 2026 | 0 |
| Bmal1 Regulates Vascular Calcification via Noncanonical Circadian Pathway-Brief [PMID:41608773] | He M, Sun Y, Tang C, Huang F, Zhu Z et a | Arterioscler Thromb Vasc Biol | 2026 | 0 |
| Liver-specific knockout of CD73 exacerbated alcohol-associated steatohepatitis b [PMID:41833677] | Wu X, Zhang Q, Wang QQ, Liu ZN, Ni YY et | Int J Biol Macromol | 2026 | 0 |
| Circadian disruption and its clinical implications in Parkinson's disease: A Nar [PMID:41905255] | Kataoka H, Saeki K, Sugie K, Obayashi K | Sleep medicine | 2026 | 0 |
| The neuroprotective role of eugenol against glyphosate-induced toxicity in rats: [PMID:41922126] | Bolat İ, Alat Ö, Orhan B, Dereli E, Teki | Tissue & cell | 2026 | 0 |
| Circadian abnormalities, molecular clock gene and chronobiological treatment for [PMID:41913359] | Chakraborty S, Srivastava V | Chronobiology international | 2026 | 0 |
| The rhythm of decline: Circadian disruption in neurodegeneration. [PMID:41066745] | Singh J, Kumar D, Kaur J, Singh A | Journal of food and drug analy | 2025 | 0 |
| Core Circadian Protein BMAL1: Implication for Nervous System Functioning and Its [PMID:41440117] | Smirnova KV, Smirnova LP, Amstislavskaya | Brain sciences | 2025 | 0 |
| Pharmacological targeting of BMAL1 modulates circadian and immune pathways. [PMID:40133642] | Pu H, Bailey LC, Bauer LG, Voronkov M, B | Nature chemical biology | 2025 | 0 |
| Circadian Rhythm Dysfunction in Neurodegenerative Diseases: A Bidirectional Pers [PMID:41287625] | Namgyal D, Lim CS | Nature and science of sleep | 2025 | 0 |
| Disrupted circadian control promotes oncogenesis in breast cancer. [PMID:41908013] | Fatima Y, Kashif M, Jain PA | Bioinformation | 2025 | 0 |
| Disruption of the circadian clock component BMAL1 elicits an endocrine adaption [PMID:35238641] | Jouffe C, Weger BD, Martin E, Atger F, W | Proceedings of the National Ac | 2022 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.95 · 2026-04-11
closed · Rounds: 4 · Score: 0.95 · 2026-04-09
closed · Rounds: 4 · Score: 0.93 · 2026-04-06
Hypotheses and analyses mentioning CIRCADIAN_RHYTHM in their description or question text
No additional research found