gene

CHMP5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHMP5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

4Outgoing

2Incoming

0Experiments

0Debates

Summary

CHMP5 - ESCRT-III associated protein regulating MVB formation, autophagy, and endosomal trafficking

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🧬 Gene Info

Gene Symbol	CHMP5
Full Name	Charged Multivesicular Body Protein 5
Function	is a member of the CHMP (Charged Multivesicular Body Protein) family, which includes CHMP1-7.
Ensembl ID	ENSG00000089006
GeneCards	CHMP5
Human Protein Atlas	CHMP5
Multivesicular body formation	Sorting ubiquitinated proteins into intralumenal vesicles
Autophagosome-lysosome fusion	Facilitating the degradation of cargo through autophagy
Membrane remodeling	Critical for endosomal maturation and trafficking
Associated Diseases	neurodegeneration
Interactions	CHMP6
KG Connections	6 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CHMP5 — Charged Multivesicular Body Protein 5

gene · 546 words

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Pathway Diagram

flowchart TD
    N0["CHMP5"]
    N1["CHMP6"]
    N0 -->|"co expressed with"| N1
    N2["GSDMD"]
    N0 -->|"co expressed with"| N2
    N3["CHMP2A"]
    N3 -->|"co expressed with"| N0
    N4["CHMP4B"]
    N4 -->|"co expressed with"| N0
    N5["neurodegeneration"]
    N0 -->|"implicated in"| N5

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene
    class N2 protein
    class N3 gene
    class N4 gene

Outgoing (4)

Target	Relation	Type	Str
CHMP6	activates	gene	0.60
ferroptosis	participates_in	pathway	0.60
CHMP6	co_expressed_with	gene	0.50
GSDMD	co_expressed_with	protein	0.50

Incoming (2)

Source	Relation	Type	Str
CHMP2A	co_expressed_with	gene	0.50
CHMP4B	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CHMP5 in their description or question text

No additional research found