protein

CERULOPLASMIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CERULOPLASMIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

3Outgoing

2Incoming

0Experiments

0Debates

Summary

Multicopper oxidase critical for iron and copper metabolism, linked to PD and aceruloplasminemia

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🔬 Protein Info

Gene Symbol	CERULOPLASMIN
Function	Ceruloplasmin is a multi-copper ferroxidase essential for systemic and brain iron metabolism
Molecular Weight	151 kDa
Amino Acids	1046 aa
GeneCards	CERULOPLASMIN
Human Protein Atlas	CERULOPLASMIN
Six copper atoms	Three type I coppers (blue), one type II, two type III
Three plastocyanin-like domains	Sixfold internal sequence repeat
Iron-binding sites	Multiple sites for substrate Fe2+ binding
GPI-anchor site	Alternative C-terminus for membrane attachment in brain
Iron efflux from brain	Works with ferroportin to export iron
Neuronal iron supply	Generates transferrin-bound iron for neurons
Associated Diseases	neurodegeneration
KG Connections	4 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Ceruloplasmin (CP)

protein · 756 words

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Pathway Diagram

flowchart TD
    CERULOPLASMIN(["CERULOPLASMIN"])
    GENES(["GENES"])
    AND(["AND"])
    CATHEPSIN_B(["CATHEPSIN B"])
    Proteins(["Proteins"])
    neurodegeneration["neurodegeneration"]

    GENES -->|"biomarker for"| CERULOPLASMIN
    AND -->|"associated with"| CERULOPLASMIN
    CERULOPLASMIN -->|"expressed in"| CATHEPSIN_B
    CERULOPLASMIN -->|"expressed in"| Proteins
    CERULOPLASMIN -->|"implicated in"| neurodegeneration

    style CERULOPLASMIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (3)

Target	Relation	Type	Str
Ferroptosis	protects_against	process	0.80
CATHEPSIN B	expressed_in	protein	0.50
Proteins	expressed_in	protein	0.50

Incoming (2)

Source	Relation	Type	Str
GENES	biomarker_for	gene	0.60
AND	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CERULOPLASMIN in their description or question text

No additional research found