gene

CCDC88A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCDC88A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

5Outgoing

2Incoming

0Experiments

0Debates

Summary

Page for CCDC88A — Coiled-Coil Domain Containing 88A

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	CCDC88A
Full Name	Coiled-Coil Domain Containing 88A
Function	CCDC88A, also known as Girdin (G protein-interacting protein, also called Akt1/PKB interacting protein), is an actin-binding protein that plays critical roles in cytoskeletal dynamics, cell migration,
Primary Expression	the developing brain and continues to be expressed in adult neurons, particularly in the hippocampus and cerebral [corte
Pathways	PI3K
UniProt ID	CCDC88A
Ensembl ID	ENSG00000115355
GeneCards	CCDC88A
Human Protein Atlas	CCDC88A
Actin cytoskeleton regulation	Modulates actin filament assembly and organization
Cell migration	Essential for neuronal migration during development
Signal transduction	Modulates PI3K/Akt signaling pathway
Synaptic plasticity	Involved in dendritic spine formation and function
Associated Diseases	cancer
Interactions	AND, CX43, GENES
KG Connections	7 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CCDC88A — Coiled-Coil Domain Containing 88A

gene · 818 words

→

Pathway Diagram

flowchart TD
    N0["CCDC88A"]
    N1["Tumor"]
    N0 -->|"activates"| N1
    N2["Cancer"]
    N0 -->|"associated with"| N2
    N3["CX43"]
    N0 -->|"activates"| N3
    N4["CANCER"]
    N0 -->|"associated with"| N4
    N5["GENES"]
    N5 -->|"activates"| N0
    N6["AND"]
    N6 -->|"activates"| N0
    N7["cancer"]
    N0 -->|"associated with"| N7
    N8["METASTASIS"]
    N0 -->|"associated with"| N8
    N9["neurodegeneration"]
    N0 -->|"implicated in"| N9

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 disease

Outgoing (5)

Target	Relation	Type	Str
Tumor	activates	disease	0.65
Cancer	associated_with	disease	0.65
CX43	activates	gene	0.60
CANCER	associated_with	gene	0.60
cancer	associated_with	disease	0.50

Incoming (2)

Source	Relation	Type	Str
GENES	activates	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CCDC88A in their description or question text

No additional research found