gene

arhgap26

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about arhgap26: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

5Outgoing

5Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ARHGAP26
Full Name	Rho GTPase Activating Protein 26
Chromosome	5q31.3
Protein Type	Gene
Function	is a Rho GTPase-activating protein (GAP) that regulates the Rho family of small GTPases, including RhoA, Rac1, and Cdc42.
Primary Expression	neurons and glial cells, where it regulates the actin cytoskeleton dynamics critical for neuronal morphogenesis, synapse formation, and plasticity
Molecular Weight	84 kDa
Amino Acids	753 aa
GeneCards	ARHGAP26
Human Protein Atlas	ARHGAP26
Associated Diseases	ALS pathogenesis
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ARHGAP26 — Rho GTPase Activating Protein 26

gene · 1502 words

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Pathway Diagram

flowchart TD
    N0["ARHGAP26"]
    N1["Als"]
    N0 -->|"therapeutic target"| N1
    N2["Ms"]
    N0 -->|"therapeutic target"| N2
    N3["Cancer"]
    N0 -->|"therapeutic target"| N3
    N4["Carcinoma"]
    N0 -->|"therapeutic target"| N4
    N5["HIPPO"]
    N5 -->|"therapeutic target"| N0
    N6["RHOA"]
    N6 -->|"associated with"| N0
    N7["CANCER"]
    N7 -->|"therapeutic target"| N0
    N8["CDH1"]
    N8 -->|"associated with"| N0
    N9["neurodegeneration"]
    N0 -->|"implicated in"| N9

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 disease
    class N4 disease
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene

Outgoing (5)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ARHGAP26	data_in	dataset_row	0.00
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65

Incoming (5)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ARHGAP26	data_in	dataset_row	0.00
HIPPO	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
CDH1	associated_with	gene	0.60
RHOA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning arhgap26 in their description or question text

No additional research found