Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ALS pathogenesis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| 35767949 | contributes to | paper | 0.90 |
| Autophagy Dysfunction | contributes_to | process | 0.85 |
| ATXN2 | contributes_to | gene | 0.85 |
| Non-Cell Autonomous Autophagy Dysfunction | contributes_to | mechanism | 0.75 |
| gene processing | regulates | pathway | 0.70 |
| 33918092 | may play a role in | paper | 0.60 |
| 39317854 | may contribute to | paper | 0.30 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 3 hypotheses Top: 0.750
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.584
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.78 · 2026-04-26
closed · Rounds: 4 · Score: 0.63 · 2026-04-13
Hypotheses and analyses mentioning ALS pathogenesis in their description or question text
No additional research found