Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NLRP3, CASP1, IL1B, PYCARD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | NLRP3, CASP1, IL1B, PYCARD |
| Key Genes/Proteins | AHR, IL10, TGFB1, CLDN1, OCLN, ZO1, MLCK, GLP1R, GLP1R, BDNF, NLRP3, SNCA |
| Related Diseases | neurodegeneration |
graph TD
NLRP3__CASP1__IL1B__PYCARD[NLRP3, CASP1, IL1B, PYCARD]
NLRP3__CASP1__IL1B__PYCARD -->|debate_co_mention| SNCA[SNCA]
NLRP3__CASP1__IL1B__PYCARD -->|debate_co_mention| SNCA__HSPA1A__DNMT1[SNCA, HSPA1A, DNMT1]
NLRP3__CASP1__IL1B__PYCARD -->|debate_co_mention| TH__AADC[TH, AADC]
NLRP3__CASP1__IL1B__PYCARD -->|debate_co_mention| TLR4__SNCA[TLR4, SNCA]
NLRP3__CASP1__IL1B__PYCARD -->|implicated in| neurodegeneration[neurodegeneration]
NLRP3__CASP1__IL1B__PYCARD -->|data_in| benchmark_ot_ad_answer_key_NLR[benchmark_ot_ad_answer_key:NLRP3, CASP1, IL1B, PYCARD]
h_e7e1f943[h-e7e1f943] -->|targets| NLRP3__CASP1__IL1B__PYCARD
GLP1R[GLP1R] -->|debate_co_mention| NLRP3__CASP1__IL1B__PYCARD
GLP1R__BDNF[GLP1R, BDNF] -->|debate_co_mention| NLRP3__CASP1__IL1B__PYCARD
neuroinflammation[neuroinflammation] -->|debate_co_mention| NLRP3__CASP1__IL1B__PYCARD
NLRP3[NLRP3] -->|debate_co_mention| NLRP3__CASP1__IL1B__PYCARD
CLDN1__OCLN__ZO1__MLCK[CLDN1, OCLN, ZO1, MLCK] -->|co_associated_with| NLRP3__CASP1__IL1B__PYCARD
AHR__IL10__TGFB1[AHR, IL10, TGFB1] -->|co_associated_with| NLRP3__CASP1__IL1B__PYCARD
benchmark_ot_ad_answer_key_NLR -->|data_in| NLRP3__CASP1__IL1B__PYCARD| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:NLRP3, CASP1, IL1B, PYCARD | data_in | dataset_row | 0.00 |
| SNCA | debate_co_mention | gene | 0.45 |
| SNCA, HSPA1A, DNMT1 | debate_co_mention | gene | 0.45 |
| TH, AADC | debate_co_mention | gene | 0.45 |
| TLR4, SNCA | debate_co_mention | gene | 0.45 |
| SNCA, HSPA1A, DNMT1 | co_associated_with | gene | 0.40 |
| TH, AADC | co_associated_with | gene | 0.40 |
| TLR4, SNCA | co_associated_with | gene | 0.40 |
| neurodegeneration | associated_with | disease | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:NLRP3, CASP1, IL1B, PYCARD | data_in | dataset_row | 0.00 |
| h-e7e1f943 | targets | hypothesis | 0.50 |
| GLP1R | debate_co_mention | gene | 0.45 |
| GLP1R, BDNF | debate_co_mention | gene | 0.45 |
| neuroinflammation | debate_co_mention | process | 0.45 |
| NLRP3 | debate_co_mention | gene | 0.45 |
| GLP1R, BDNF | co_associated_with | gene | 0.40 |
| AHR, IL10, TGFB1 | co_associated_with | gene | 0.40 |
| CLDN1, OCLN, ZO1, MLCK | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming | 0.907 | neurodegeneration | What are the mechanisms by which gut mic |
| Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S | 0.822 | neurodegeneration | What are the mechanisms by which gut mic |
| Microbial Inflammasome Priming Prevention | 0.653 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.907
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe | clinical | Neurodegeneration | 0.400 | 0.50 | in_silico | proposed | $180,000 |
| Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiation Mechanis | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Antiviral Therapy Trial for Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Experiment: Autoimmune Hypothesis Testing in AD | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| cGAS-STING Pathway Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
| Microbiome-Gut Barrier Signatures in ALS — Experiment Design | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism and inter | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| NLRP3 Inflammasome Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Regulated Necrosis Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Systemic inflammation as a central player in the initiation and development of A [PMID:40841660] | Bayraktaroglu I, Ortí-Casañ N, Van Dam D | Immunity & ageing : I & A | 2025 | 1 |
| USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent au [PMID:35900990] | ["Di Q", "Zhao X", "Tang H", "Li X", "Xi | Autophagy | 2023 | 1 |
| USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradatio [PMID:34486483] | ["Cai B", "Zhao J", "Zhang Y", "Liu Y", | Autophagy | 2022 | 1 |
| Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861] | ["Han X", "Sun S", "Sun Y", "Song Q", "Z | Autophagy | 2020 | 1 |
| Interweaving microglial senescence and gut microbiome dynamics in Alzheimer's di [PMID:41747877] | Waghmare A, Rahangdale S, Khare K, Taksa | Molecular and cellular neurosc | 2026 | 0 |
| The Immuno-Glial Connectome in Alzheimer's Disease: Integrating Central and Peri [PMID:41569436] | Gopalakrishna PK, Che Mohd Nassir CMN, A | Cellular and molecular neurobi | 2026 | 0 |
| Elevated expression of the NLRP3 inflammasome in post-mortem brain white matter [PMID:41687275] | Otálora-Alcaraz A, Sun MC, Hofman N, Cos | Multiple sclerosis and related | 2026 | 0 |
| NLRP3 Inflammasome and Polycystic Ovary Syndrome (PCOS): A Novel Profile in Adip [PMID:41596350] | Alenezi SA, Alshammari K, Khan R, Amer S | International journal of molec | 2026 | 0 |
| Exploring the Role of Microglial Cells in the Gut-Brain Axis Communication: A Sy [PMID:40662222] | Ortiz-Samur NS, Vijaya AK, Burokas A, Me | Journal of neurochemistry | 2025 | 0 |
| Sepsis and the Liver. [PMID:41439929] | ["Geladari E", "Kalergi A", "Evangelopou | Diseases (Basel, Switzerland) | 2025 | 0 |
| Nlrc4 Inflammasome Expression After Acute Myocardial Infarction in Rats. [PMID:40332346] | Borim PA, Gatto M, Mota GAF, Meirelles A | Int J Mol Sci | 2025 | 0 |
| Molecular links between inflammatory bowel disease and Alzheimer's disease throu [PMID:41480321] | Durairajan SSK, Singh AK, Sulaiman SM, P | World journal of gastroenterol | 2025 | 0 |
| Bone marrow vacuolization to curative strategies: Evolving paradigms in VEXAS sy [PMID:40784090] | ["Elbadry M", "Mabed M"] | Current research in translatio | 2025 | 0 |
| Δ9-Tetrahydrocannabinol and cannabidiol selectively suppress toll-like receptor [PMID:40553974] | Sermet S, Finn BM, Crawford RB, Kaminski | The Journal of pharmacology an | 2025 | 0 |
| Nlrc4 Inflammasome Expression After Acute Myocardial Infarction in Rats. [PMID:40332346] | Borim PA, Gatto M, Mota GAF, Meirelles A | International journal of molec | 2025 | 0 |
| The NLRP3-inflammasome inhibitor MCC950 improves cardiac function in a HFpEF mou [PMID:39616735] | ["Li S", "Withaar C", "Rodrigues P", "Zi | Biomedicine & pharmacotherapy | 2024 | 0 |
| Andrographolide Attenuates NLRP3 Inflammasome Activation and Airway Inflammation [PMID:38808326] | Yu Y, Miao TW, Xiao W, Mao B, Du LY, Wan | Drug design, development and t | 2024 | 0 |
| Inhibition of autophagy in microglia and macrophages exacerbates innate immune r [PMID:36652438] | Hegdekar N, Sarkar C, Bustos S, Ritzel R | Autophagy | 2023 | 0 |
| Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's [PMID:37029500] | Yan YQ, Zheng R, Liu Y, Ruan Y, Lin ZH, | Aging cell | 2023 | 0 |
| Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like [PMID:36288697] | Li S, Fang Y, Zhang Y, Song M, Zhang X, | Cell reports | 2022 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning NLRP3, CASP1, IL1B, PYCARD in their description or question text
No additional research found