gene

adcy5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about adcy5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

0Hypotheses

0Analyses

4Outgoing

5Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ADCY5
Full Name	Adenylate cyclase 5
Chromosome	3q21.1
Function	is a large integral membrane protein (approximately 150 kDa) with a characteristic architecture consisting of
Primary Expression	Highest in striatum, nucleus accumbens, cortex
Molecular Weight	150 kDa
Amino Acids	1264 aa
Exons	34
UniProt ID	[O76074](https://www.uniprot.org/uniprot/O76074)
Ensembl ID	ENSG00000108055
GeneCards	ADCY5
Human Protein Atlas	ADCY5
G protein regulation	Activated by Gαs/Gαolf subunits; inhibited by Gαi/o subunits
Forskolin sensitivity	AC5 is highly responsive to forskolin, a plant diterpene that directly activates adenylate cyclases
Calmodulin binding	AC5 is unique among adenylate cyclases in being inhibited by calmodulin in a calcium-dependent manner
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ADCY5 Gene

gene · 1894 words

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Pathway Diagram

flowchart TD
    N0["ADCY5"]
    N1["BAI1"]
    N0 -->|"associated with"| N1
    N2["Complement"]
    N0 -->|"regulates"| N2
    N3["C1Q"]
    N0 -->|"associated with"| N3
    N4["CD44"]
    N4 -->|"associated with"| N0
    N5["COMPLEMENT"]
    N5 -->|"regulates"| N0
    N3 -->|"associated with"| N0
    N6["MET"]
    N6 -->|"associated with"| N0
    N7["AND"]
    N7 -->|"associated with"| N0
    N8["neurodegeneration"]
    N0 -->|"implicated in"| N8

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 gene
    class N2 pathway
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene

Outgoing (4)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ADCY5	data_in	dataset_row	0.00
Complement	regulates	pathway	0.60
BAI1	associated_with	gene	0.60
C1Q	associated_with	gene	0.60

Incoming (5)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ADCY5	data_in	dataset_row	0.00
COMPLEMENT	regulates	gene	0.60
CD44	associated_with	gene	0.60
C1Q	associated_with	gene	0.60
MET	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning adcy5 in their description or question text

No additional research found