gene

abcg4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about abcg4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

18Outgoing

10Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ABCG4
Full Name	ABCG4 — ATP-Binding Cassette Subfamily G Member 4
Aliases	ATP-Binding Cassette Subfamily G Member 4
Chromosome	11q22.3
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the brain and is involved in cholesterol and lipid transport, with emerging roles in neurodegenerative disease pathogenesis
Molecular Weight	71 kDa
Amino Acids	646 aa
Exons	13
GeneCards	ABCG4
Human Protein Atlas	ABCG4
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ABCG4 Gene — ATP-Binding Cassette Subfamily G Member 4

gene · 1335 words

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Pathway Diagram

graph TD
    ABCG4["ABCG4"]
    ABCG4 -->|"regulates"| Alzheimer["Alzheimer"]
    ABCG4 -->|"regulates"| Als["Als"]
    ABCG4 -->|"regulates"| ALS["ALS"]
    ABCG4 -->|"regulates"| ABCA1["ABCA1"]
    ABCG4 -->|"regulates"| Cholesterol["Cholesterol"]
    ABCG4 -->|"activates"| Neuron["Neuron"]
    ABCG4 -->|"regulates"| Astrocyte["Astrocyte"]
    ABCG4 -->|"regulates"| ASTROCYTES["ASTROCYTES"]
    ATP["ATP"] -->|"regulates"| ABCG4
    ALZHEIMER["ALZHEIMER"] -->|"regulates"| ABCG4
    ABCG1["ABCG1"] -->|"regulates"| ABCG4
    APOE["APOE"] -->|"regulates"| ABCG4
    ASTROCYTES -->|"regulates"| ABCG4
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"regulates"| ABCG4
    AND["AND"] -->|"regulates"| ABCG4
    ABCA1 -->|"regulates"| ABCG4

Outgoing (18)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ABCG4	data_in	dataset_row	0.00
ALS	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Cholesterol	regulates	pathway	0.60
Neuron	activates	cell_type	0.60
Astrocyte	regulates	cell_type	0.60
neurons	expressed_in	cell_type	0.60
ABCA1	regulates	gene	0.60
ABCG1	regulates	gene	0.60
APOE	regulates	gene	0.60
ATP	regulates	gene	0.60
Raf	regulates	protein	0.60
Ras	activates	protein	0.60
ASTROCYTES	regulates	gene	0.60
Ca1	expressed_in	brain_region	0.55
Astrocyte	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (10)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ABCG4	data_in	dataset_row	0.00
genes-abcg4	describes	wiki_page	0.95
ABCA1	regulates	gene	0.60
ALZHEIMER DISEASE	regulates	gene	0.60
AND	regulates	gene	0.60
ATP	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
ASTROCYTES	regulates	gene	0.60
ABCG1	regulates	gene	0.60
APOE	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning abcg4 in their description or question text

No additional research found