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YKL-40 (Chitinase-3-like protein 1)

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wiki page Created: 2026-04-02T20:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-biomarkers-ykl40

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biomarkers-ykl40

🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

📊 Evidence Profile

Evidence Balance

+0%

Certainty

100%

Debates

0

Incoming

24

Outgoing

38

0 supporting 0 contradicting 0 neutral

View full evidence profile →

Linked Artifacts (62)

mentions🔬Neuroinflammation and microglial priming in early Alzheimer&75%

mentions🧫Progranulin Replacement Therapy for FTD — Vector Development70%

mentions🧫Prodromal Parkinson's Disease Biomarker Development — E70%

mentions🧫Microglial Contributions to Huntington's Disease Pathog70%

mentions🧫CHI3L1 variant association with AD progression in human pati70%

mentions🧫NPH Glymphatic System Interaction Experiment70%

mentions🧫Traumatic Brain Injury and Alzheimer's Disease Relation70%

mentions🧫Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer&#70%

mentions🧫Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo70%

mentions🧫SCFA-Mediated Neuroinflammation in Alzheimer's Disease70%

related🔬Neuroinflammation and microglial priming in early Alzheimer&67%

mentions🧪Mechanosensitive Ion Channel Reprogramming65%

mentions🧪Microbiome-Derived Tryptophan Metabolite Neuroprotection65%

mentions🧪Orexin-Microglia Modulation Therapy65%

related🧫Progranulin Replacement Therapy for FTD — Vector Development63%

related🧫SCFA-Mediated Neuroinflammation in Alzheimer's Disease63%

related🧫Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer&#63%

related🧫CHI3L1 variant association with AD progression in human pati63%

related🧫Microglial Contributions to Huntington's Disease Pathog63%

related🧫Traumatic Brain Injury and Alzheimer's Disease Relation63%

related🧫NPH Glymphatic System Interaction Experiment63%

related🧫Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo63%

related🧫Prodromal Parkinson's Disease Biomarker Development — E63%

related🧪Microbiome-Derived Tryptophan Metabolite Neuroprotection58%

related🧪Mechanosensitive Ion Channel Reprogramming58%

related🧪Orexin-Microglia Modulation Therapy58%

related🔬What are the mechanisms underlying digital biomarkers and ai50%

mentions🧪APOE-TREM2 Interaction Modulation50%

related🔬What are the mechanisms underlying what are the mechanisms b50%

related🔬What are the mechanisms underlying protein aggregation cross50%

related🔬What are the mechanisms underlying sleep disruption as cause50%

related🔬What are the mechanisms underlying what are the mechanisms b50%

related🧪Microglial Efferocytosis Enhancement via GPR32 Superagonists50%

mentions🧪Serine/Arginine-Rich Protein Kinase Modulation50%

mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%

mentions🧪TREM2-Mediated Selective Aggregate Clearance Pathway50%

mentions🧪TREM2-mediated microglial tau clearance enhancement50%

mentions🧫Blood Biomarker vs Tau PET for Treatment Monitoring50%

mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%

related🔬What are the mechanisms underlying astrocyte reactivity subt50%

mentions🧪Heat Shock Protein 70 Disaggregase Amplification50%

mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%

related🧪Senescent Microglia Resolution via Maresins-Senolytics Combi50%

related🔬RNA binding protein dysregulation across ALS FTD and AD50%

related🔬What are the mechanisms underlying rna binding protein dysre50%

mentions🧫iPSC-NPC effects on astrocytes in vitro ICH model50%

related🧪Metabolic Reprogramming via Microglial Glycolysis Inhibition50%

related🔬What are the mechanisms underlying astrocyte reactivity subt50%

related🔬What are the mechanisms underlying sleep disruption as cause50%

related🔬What are the mechanisms underlying tdp-43 phase separation t50%

mentions🧪Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam50%

mentions🧪TREM2-Dependent Microglial Senescence Transition50%

mentions🧪Enteric Nervous System Prion-Like Propagation Blockade50%

related🧪Enteric Nervous System Prion-Like Propagation Blockade40%

related🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas40%

mentions🔬RNA binding protein dysregulation across ALS FTD and AD40%

mentions🔬What are the mechanisms underlying rna binding protein dysre40%

related🧪Heat Shock Protein 70 Disaggregase Amplification40%

mentions🔬What are the mechanisms underlying digital biomarkers and ai40%

mentions🔬What are the mechanisms underlying protein aggregation cross40%

related🧪Serine/Arginine-Rich Protein Kinase Modulation40%

related🔬What are the mechanisms underlying tdp-43 phase separation t30%

💬 Discussion