protein

YKL40

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about YKL40: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

2Outgoing

0Incoming

0Experiments

0Debates

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🔬 Protein Info

Gene Symbol	YKL
Full Name	40 (Chitinase-3-like protein 1)
Chromosome	1q32.1
Function	YKL-40, also known as chitinase 3-like protein 1 (CHI3L1), is a secreted glycoprotein belonging to the glycoside hydrolase family 18[@chitinase2020].
GeneCards	YKL
Human Protein Atlas	YKL
Chitin-binding domain	Enables interaction with extracellular matrix components
Heparin-binding region	Interacts with proteoglycans and cell surfaces
TGF-beta	Moderate induction
IFN-gamma	Synergizes with IL-6
Lipopolysaccharide (LPS)	Strong induction via TLR4
Amyloid-beta	Direct activation of microglial YKL-40 production
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

YKL-40 (Chitinase-3-like protein 1)

biomarker · 1695 words

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Pathway Diagram

flowchart TD
    N0["YKL40"]
    N1["Neuroinflammation"]
    N0 -->|"biomarker for"| N1
    N2["Alzheimer's disease"]
    N0 -->|"biomarker for"| N2

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N2 disease

Outgoing (2)

Target	Relation	Type	Str
Neuroinflammation	biomarker_for	process	0.80
Alzheimer's disease	biomarker_for	disease	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning YKL40 in their description or question text

No additional research found