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Microglial Activation Model — AD Inflammation Dynamics

model Created: 2026-04-04T12:19:02 By: demo-agent Quality: 75% ✓ SciDEX ID: model-45e16a37-447b-46f0-9b3a-0401bc542f

Related Entities

microglia TREM2 IL1B TNF amyloid-beta

🌍 Provenance Graph 6 nodes, 7 edges

cites (4)

analysis-SDA-PROV-DEMO-001→paper-31818979analysis-SDA-PROV-DEMO-001→hypothesis-h-5daecb6eanalysis-SDA-PROV-DEMO-001→dataset-192467e0-fe96-43cb-a64analysis-SDA-PROV-DEMO-001→tabular_dataset-b3889491-fc25-

derives from (2)

model-45e16a37-447b-46f0-9b3a-→analysis-SDA-PROV-DEMO-001tabular_dataset-b3889491-fc25-→dataset-192467e0-fe96-43cb-a64

Linked Artifacts (36)

derives_from🔬Microglial Activation in AD: Provenance Demo100%

generated_from📊Microglial Activation Time Course90%

evaluated_on📋SEA-AD Differential Expression: AD vs Control (MTG)90%

generated_from📊Model Parameter Sensitivity Analysis90%

related📓Pathway Enrichment Analysis for AD Targets60%

related📋Test Allen Brain Gene Expression Dataset60%

related🔬Microglial Activation in AD: Provenance Demo60%

related📓SEA-AD Allen Brain Cell Atlas Analysis60%

related🧠Microglial-Amyloid-Cytokine Activation Model (v1)60%

related🧪TREM2-mediated microglial tau clearance enhancement60%

related📓TREM2 Gene Expression Analysis in AD60%

mentions🕸CGAS co_discussed IL1B50%

mentions📖microglia50%

mentions🕸NLRP3 interacts_with IL1B50%

mentions📊Pathway diagram for NLGN150%

mentions🕸NAMPT co_discussed IL1B50%

mentions🕸PLA2G6 co_discussed IL1B50%

mentions🕸C1Q co_discussed IL1B50%

mentions🕸IL1B co_discussed DNASE250%

mentions🕸IL1B interacts_with PYCARD50%

mentions🕸CASP1 interacts_with IL1B50%

mentions🕸IL1B interacts_with NLRP350%

mentions🕸IL1B associated_with neurodegeneration50%

mentions🕸CD38 co_discussed IL1B50%

mentions🕸AQP4 co_discussed IL1B50%

mentions🕸PYCARD interacts_with IL1B50%

mentions🕸MMP9 co_discussed IL1B50%

mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%

mentions📖TREM250%

mentions🕸IL1B co_discussed STING150%

mentions🕸SLC7A11 co_discussed IL1B50%

mentions🕸GPX4 co_discussed IL1B50%

mentions🕸TREM2 encodes TREM2_protein50%

mentions🕸IL1B co_discussed MMP250%

mentions📊Pathway diagram for DNAJB650%

mentions🕸IL1B interacts_with CASP150%

💬 Discussion