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Cognitive impact of TDP-43 pathology in AD patients

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experiment Created: 2026-04-06T19:29:12 By: experiment_extractor Quality: 70% ✓ SciDEX ID: experiment-exp-1f297f00-3d27-4c16-bfb2-d

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🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

experiment-exp-1f297f00-3d27-4→paper-34930382

📊 Evidence Profile

Evidence Balance

+0%

Certainty

100%

Debates

0

Incoming

54

Outgoing

55

0 supporting 0 contradicting 0 neutral

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Linked Artifacts (103)

related🧪Cross-Seeding Prevention Strategy100%

related🧪Cryptic Exon Silencing Restoration100%

related🧪RNA-Binding Competition Therapy for TDP-43 Cross-Seeding100%

derives_from📄TDP-43 Pathology in Alzheimer's Disease.100%

related🧪Glycine-Rich Domain Competitive Inhibition100%

related🧫TDP-43 pathology prevalence and distribution in AD cases100%

mentions📖TARDBP — TAR DNA Binding Protein 4390%

mentions📖TARDBP — TAR DNA Binding Protein 4380%

mentions📖TARDBP Mutations in Amyotrophic Lateral Sclerosis80%

mentions📖TARDBP/TDP-43 Protein80%

mentions📖tardbp80%

related📖TARDBP Mutations in Amyotrophic Lateral Sclerosis72%

related📖TARDBP — TAR DNA Binding Protein 4372%

related📖TARDBP/TDP-43 Protein72%

related📖tardbp72%

mentions📖TDP-43 Co-pathology in Corticobasal Syndrome70%

mentions📖TDP-43 Protein70%

mentions📖TDP-43 Proteinopathy Neurons70%

mentions📖TDP-43 PET Ligand Development for FTD and ALS70%

mentions📖TDP-43 vs Tau Pathology Determination in GRN vs MAPT Mutatio70%

mentions📖TDP-43 Pathology in Corticobasal Syndrome70%

mentions📖TDP-43 Proteinopathy Neurons in Frontotemporal Dementia70%

mentions📖TDP-43 Pathology Reversibility in ALS70%

mentions📖proteins-tar-db-protein70%

mentions📖TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis70%

mentions📖cell-types-tdp-43-proteinopathy-neurons70%

mentions📖tdp-43-fus-rna-proteinopathy-comparison70%

mentions📖TDP-43 Protein70%

mentions📖TDP-43 (TAR DNA-Binding Protein 43) - Biomarker70%

mentions📖TDP-43 Proteinopathy in ALS70%

mentions📖TDP-43 RNA Granule Pathway70%

mentions📖gaps-tdp-43-pet-ligand-ftd70%

mentions📖TDP-43 Proteinopathy70%

mentions📖TDP-43 Splicing Modulation Therapy70%

mentions📖TDP-43 Pathology in Corticobasal Syndrome70%

mentions📖TDP-43 Aggregate Neurons70%

mentions📖TDP-43 Proteinopathy Investment Landscape70%

mentions📖TDP-43 DNA Repair Mechanism in ALS and Dementia70%

mentions📖proteins-tdp43_protein70%

related📖TDP-43 Splicing Modulation Therapy63%

related📖TDP-43 Proteinopathy Investment Landscape63%

related📖TDP-43 Co-pathology in Corticobasal Syndrome63%

related📖proteins-tdp43_protein63%

related📖TDP-43 Protein63%

related📖TDP-43 Protein63%

related📖TDP-43 (TAR DNA-Binding Protein 43) - Biomarker63%

related📖gaps-tdp-43-pet-ligand-ftd63%

related📖TDP-43 Proteinopathy Neurons63%

related📖TDP-43 Aggregate Neurons63%

related📖TDP-43 Pathology Reversibility in ALS63%

related📖cell-types-tdp-43-proteinopathy-neurons63%

related📖TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis63%

related📖TDP-43 Proteinopathy63%

related📖TDP-43 Pathology in Corticobasal Syndrome63%

related📖TDP-43 RNA Granule Pathway63%

related📖tdp-43-fus-rna-proteinopathy-comparison63%

related📖TDP-43 vs Tau Pathology Determination in GRN vs MAPT Mutatio63%

related📖TDP-43 PET Ligand Development for FTD and ALS63%

related📖TDP-43 DNA Repair Mechanism in ALS and Dementia63%

related📖proteins-tar-db-protein63%

related📖TDP-43 Proteinopathy Neurons in Frontotemporal Dementia63%

related📖TDP-43 Pathology in Corticobasal Syndrome63%

related📖TDP-43 Proteinopathy in ALS63%

related🧫cGAS/STING pathway validation in TDP-43 mutant mice60%

related🧫cGAMP biomarker analysis in ALS patient spinal cord samples60%

mentions📖Preclinical Alzheimer's Disease60%

mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%

related🧪Cross-Seeding Prevention Strategy60%

related🧫TDP-43 mitochondrial invasion and DNA release via mPTP60%

mentions📖Alzheimer's Disease60%

mentions📖PSEN2 Mutations in Alzheimer's Disease60%

mentions📖Agitation in Alzheimer's Disease60%

related📓Cryptic Exon Silencing Restoration -- Computational Analysis60%

mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%

related🧫TDP-43 mutant mouse model cGAS/STING pathway analysis60%

related🧪RNA-Binding Competition Therapy for TDP-43 Cross-Seeding60%

mentions📖Alzheimer's Disease Genetic Variants60%

mentions📖Early-Onset Alzheimer's Disease (EOAD)60%

mentions📖TREM2 Variants in Alzheimer's Disease60%

related📖Alzheimer's Disease60%

related🧫TDP-43 pathology prevalence and distribution in AD cases60%

related🧫TDP-43 mitochondrial invasion and mtDNA release in iPSC moto60%

mentions📖APP Mutations in Alzheimer's Disease60%

mentions📖Prodromal Alzheimer's Disease60%

related🧪Glycine-Rich Domain Competitive Inhibition60%

mentions📖PSEN1 Mutations in Alzheimer's Disease60%

mentions📖Investment Landscape: Alzheimer's Disease60%

mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%

related🧪Cryptic Exon Silencing Restoration60%

related📖Alzheimer's Disease Genetic Variants54%

related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%

related📖Preclinical Alzheimer's Disease54%

related📖Alzheimer's Disease54%

related📖Early-Onset Alzheimer's Disease (EOAD)54%

related📖TREM2 Variants in Alzheimer's Disease54%

related📖Alzheimer's Disease vs Parkinson's Disease Compari54%

related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%

related📖Agitation in Alzheimer's Disease54%

related📖APP Mutations in Alzheimer's Disease54%

related📖PSEN1 Mutations in Alzheimer's Disease54%

related📖Prodromal Alzheimer's Disease54%

related📖Investment Landscape: Alzheimer's Disease54%

related📖PSEN2 Mutations in Alzheimer's Disease54%

💬 Discussion