concept

TRIM45

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRIM45: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

0Hypotheses

0Analyses

19Outgoing

4Incoming

0Experiments

0Debates

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💡 Concept Info

Name	TRIM45
Key Genes/Proteins	ATG5, MICROGLIA, NEUROINFLAMMATION, NLRP3, PYROPTOSIS
Related Diseases	Inflammation, Inflammatory Diseases, Neuroinflammation, Septic Encephalopathy
Related Pathways	pyroptosis, Pyroptosis

Pathway Diagram

graph TD
    TRIM45["TRIM45"]
    TRIM45 -->|"regulates"| Microglial_Pyroptosis["Microglial Pyroptosis"]
    TRIM45 -->|"interacts"| ATG5["ATG5"]
    TRIM45 -->|"interacts"| NLRP3["NLRP3"]
    TRIM45 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    TRIM45 -->|"regulates"| Inflammation["Inflammation"]
    TRIM45 -->|"regulates"| PYROPTOSIS["PYROPTOSIS"]
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"regulates"| TRIM45
    MICROGLIA["MICROGLIA"] -->|"regulates"| TRIM45
    PYROPTOSIS -->|"regulates"| TRIM45

Outgoing (19)

Target	Relation	Type	Str
Microglial Pyroptosis	regulates	process	0.90
ATG5	interacts_with	protein	0.85
NLRP3	interacts_with	protein	0.85
Septic Encephalopathy	associated_with	disease	0.85
Microglial Pyroptosis	upregulates	process	0.85
ATG5	activates	gene	0.80
Inflammatory Diseases	associated_with	disease	0.75
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
MICROGLIA	regulates	gene	0.60
ATG5	associated_with	gene	0.60
Pyroptosis	regulates	pathway	0.60
PYROPTOSIS	regulates	gene	0.60
Microglia	regulates	cell_type	0.60
pyroptosis	associated_with	process	0.60
pyroptosis	regulates	process	0.60
microglia	expressed_in	cell_type	0.60
pyroptosis	participates_in	pathway	0.60
Microglia	expressed_in	cell_type	0.55

Incoming (4)

Source	Relation	Type	Str
MICROGLIA	regulates	gene	0.60
PYROPTOSIS	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
NLRP3	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRIM45 in their description or question text

No additional research found