| Gene Symbol | SREBF1 (SREBP1) |
| Full Name | Sterol Regulatory Element Binding Transcription Factor 1 |
| Chromosome | 17p11.2 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | ** | ER (precursor), Golgi (processing), Nucleus (active) | |
| Pathways | NF-κB |
| UniProt ID | P36956 |
| NCBI Gene ID | 6720 |
| Ensembl ID | ENSG00000172318 |
| OMIM | 184756 |
| Cleavage Sites | SREBP1 is cleaved at two sites (Site-1 and Site-2) by resident Golgi proteases (S1P and S2P), releasing the active N-terminal fragment into the cytosol for nuclear translocation. |
| Fatty Acid Synthesis | ACC (acetyl-CoA carboxylase), FAS (fatty acid synthase), SCD1 (stearoyl-CoA desaturase) |
| Triglyceride Synthesis | GPAT (glycerol-3-phosphate acyltransferase), DGAT (diacylglycerol acyltransferase) |
| Phospholipid Synthesis | CTP:phosphocholine cytidylyltransferase |
| HMG-CoA Reductase | Rate-limiting enzyme in cholesterol synthesis |
| Associated Diseases | AD, ADH, Aging, Als, Alzheimer |
| Known Drugs/Compounds | rapamycin |
| Interactions | A2M, ACACA, ACOX1, Adiponectin, ADIPOQ, ALDH2 |
| KG Connections | 603 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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