| Gene Symbol | SHP2 |
| Aliases | Src Homology 2 Domain-Containing Phosphatase 2 |
| Chromosome | 12q24.13 |
| Function | The PTPN11 gene (located on chromosome 12q24.13 in humans) encodes a protein of 593 amino acids with a molecular weight of approximately 68 kDa. |
| Subcellular Localization | are tightly regulated, with dysregulation contributing to neuronal dysfunction a |
| Molecular Weight | 68 kDa |
| Amino Acids | 593 aa |
| GeneCards | SHP2 |
| Human Protein Atlas | SHP2 |
| Brain | Particularly in the cortex, hippocampus, and basal ganglia |
| Neurons | Both excitatory glutamatergic and inhibitory GABAergic neurons |
| Astrocytes | Supporting neuronal function |
| Microglia | Immune cells of the CNS |
| Peripheral tissues | Heart, lung, kidney, and others |
| Interactions | IL-10, PKA |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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