| Gene Symbol | SCN4A |
| Full Name | Sodium Voltage-Gated Channel Alpha Subunit 4 |
| Aliases | Nav1.4 |
| Chromosome | 17q23.3 |
| Protein Type | Voltage-gated sodium channel (Nav channel) |
| Function | is a canonical excitability gene with well-established disease associations in periodic paralysis and nondystrophic myotonia[@cannon2018][@ptacek2000][@cannon2010]. |
| Primary Expression | skeletal muscle, research has revealed important connections to neurodegenerative diseases[@waerman2020][@finsterer2019][@van2010]: |
| Subcellular Localization | </b></td><td>Plasma Membrane (Skeletal Muscle)</td></tr> |
| Molecular Weight | 260 kDa |
| UniProt ID | Q9UQD0 (Nav1.4) |
| NCBI Gene ID | 6328 |
| Ensembl ID | ENSG00000007314 |
| GeneCards | SCN4A |
| Human Protein Atlas | SCN4A |
| Four voltage-sensing domains (VSD) | Each domain contains a positively charged S4 helix that moves in response to membrane depolarization |
| Associated Diseases | Ataxia, Ms, Parkinson |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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