| Gene Symbol | LIFRPROTEIN |
| Chromosome | 5p13.1 |
| Protein Type | Receptor |
| Function | is a critical cytokine receptor that mediates the effects of leukemia inhibitory factor (LIF) and related cytokines of the interleukin-6 (IL-6) family. |
| Molecular Weight | ~190 kDa (full-length) |
| Amino Acids | 800 aa |
| Exons | 20 |
| UniProt ID | P30203 |
| GeneCards | LIFRPROTEIN |
| Human Protein Atlas | LIFRPROTEIN |
| Full-length LIFR (LIFRα) | Membrane-bound receptor with full signaling capacity |
| Soluble LIFR (sLIFR) | Truncated isoform generated by alternative splicing or proteolytic cleavage; acts as a natural antagonist by sequestering LIF |
| Associated Diseases | neurodegeneration |
| Interactions | BDNF, BRD4, CANCER, EP300, JAK1, LIF |
| KG Connections | 32 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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