protein 627 words KG: KCNN3PROTEIN
Contents

KCNN3 Protein (Small Conductance Calcium-Activated Potassium Channel 3)

🔬 Protein Info
Gene SymbolKCNN3
Full NamePotassium Calcium-Activated Channel Subfamily N Member 3
AliasesSmall Conductance Calcium-Activated Potassium Channel 3
Chromosome4q22.1
Protein FamilySK/IK calcium-activated potassium channel family
Protein TypeChannel
Functionis a member of the calcium-activated potassium channel family that plays a critical role in regulating neuronal excitability and synaptic transmission.
Molecular Weight70 kDa
Amino Acids731 aa
Exons10
UniProt ID[Q9GZP1](https://www.uniprot.org/uniprot/Q9GZP1)
Ensembl IDENSG00000163631
OMIM609923
GeneCardsKCNN3
Human Protein AtlasKCNN3
Associated DiseasesAlzheimer, Inflammation, Ms, Parkinson
Known Drugs/CompoundsTriarylmethane-34
InteractionsMAPT, SNCA
KG Connections27 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (9)

APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Senescence-Activated NAD+ Depletion Rescue
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Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (13)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (2)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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