| Gene Symbol | IP3RPROTEIN |
| Protein Type | Channel |
| Function | is a large calcium release channel located on the endoplasmic reticulum (ER) membrane. |
| Molecular Weight | 314 kDa |
| GeneCards | IP3RPROTEIN |
| Human Protein Atlas | IP3RPROTEIN |
| N-terminal IP₃-binding domain | High-affinity IP₃ binding (suppressor domain) |
| Large regulatory domain | Contains regulatory sites for Ca²⁺, ATP, and modulators |
| Central modulatory domain | Includes IRAG (IP₃R-associated protein) binding |
| Six transmembrane domains (TM1-6) | Form the ion channel pore |
| C-terminal gatekeeper domain | Channel gating regulation |
| IP₃R1 | Brain, cerebellum (highest expression) |
| IP₃R2 | Glial cells, liver, cardiac muscle |
| IP₃R3 | Widespread, secretory cells |
| Associated Diseases | neurodegeneration |
| Interactions | BCL2, CKB |
| KG Connections | 6 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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