| Gene Symbol | FIG4 |
| Full Name | FIG4 Phosphatase Homolog |
| Aliases | FIG4PROTEIN |
| Protein Type | Phosphatase |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | specific membrane compartments |
| Amino Acids | 559 aa |
| Pathways | PI3K |
| Ensembl ID | ENSG00000112367 |
| GeneCards | FIG4 |
| Human Protein Atlas | FIG4 |
| 5-phosphatase domain | The catalytic core of the protein (~300 amino acids) that hydrolyzes PIP2 and PIP3. This domain contains the signature active site motifs required for phosphatase activity. |
| C2 domain | A calcium-dependent membrane targeting domain that facilitates association with lipid membranes. This domain allows FIG4 to localize to specific membrane compartments. |
| Proline-rich region | An extended proline-rich segment that mediates protein-protein interactions with SH3 domain-containing proteins. |
| N-terminal regulatory region | Contains sites for phosphorylation and protein interactions that modulate FIG4 activity. |
| Associated Diseases | Als, Amyotrophic Lateral Sclerosis, Dementia, frontotemporal dementia, Ftd |
| Interactions | C9ORF72, C9ORF72 REPEAT EXPANSION |
| KG Connections | 131 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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