| Gene Symbol | APH1A |
| Aliases | Page for APH1A Gene, Page for APH1A Protein |
| Chromosome | 1p36.22 |
| Protein Family | Aph-1 family (gamma-secretase) |
| Function | ### Gamma-Secretase Complex Component |
| Primary Expression | Brain (cerebral cortex, hippocampus, cerebellum), Heart, Liver, Kidney, Pancreas |
| Subcellular Localization | Endoplasmic reticulum, Golgi, plasma membrane |
| Molecular Weight | 28.5 kDa |
| Amino Acids | 257 aa |
| Pathways | notch, Notch signaling |
| UniProt ID | Q9Y6X0 |
| Ensembl ID | ENSG00000144024 |
| GeneCards | APH1A |
| Human Protein Atlas | APH1A |
| Seven transmembrane helices | Spans the membrane multiple times |
| Associated Diseases | Alzheimer's Disease, Familial Alzheimer's Disease |
| Interactions | APH1B, PSEN1, PSEN2 |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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