| Gene Symbol | ANXA11 |
| Aliases | ANXA11PROTEIN |
| Chromosome | 10q22.3 |
| Function | N-terminal low-complexity domain (LCD, residues 1–188): An intrinsically disordered region enriched in glycine and proline residues. |
| Primary Expression | Motor neurons, Cortex, Hippocampus, Spinal cord |
| Subcellular Localization | </th><td>Cytoplasm; nucleus; plasma membrane; cytoskeleton</td></tr> |
| Amino Acids | 505 aa |
| UniProt ID | P50995 |
| Ensembl ID | ENSG00000122359 |
| OMIM | 602572 |
| GeneCards | ANXA11 |
| Human Protein Atlas | ANXA11 |
| N-terminal unique region | First 30-40 amino acids, contains theALS-associated mutation site (D40G) |
| Core domain | Four annexin repeats (each ~70 amino acids) that form the calcium-dependent phospholipid-binding pocket |
| Type II Ca2+ binding sites | Multiple calcium-binding motifs that mediate phospholipid binding |
| Associated Diseases | Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, FTLD-TDP, neurodegeneration, NTDs |
| Interactions | TARDBP, TDP-43 |
| KG Connections | 61 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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