| Gene Symbol | ANK1 |
| Aliases | Ankyrin 1 |
| Function | Ankyrin 1 is a membrane-associated protein that serves as a critical anchor between the plasma membrane and the underlying cytoskeleton. |
| Primary Expression | Substantia Nigra |
| Subcellular Localization | </th><td>Plasma membrane, Cytoskeleton, Axon initial segment, Nodes of Ranvier</td></tr> |
| Molecular Weight | 210 kDa |
| Pathways | Alpha-Synuclein |
| Ensembl ID | ENSG00000162678 |
| GeneCards | ANK1 |
| Human Protein Atlas | ANK1 |
| Spectrin-Binding Domain (SBD) | The central domain interacts with β-spectrin, forming the critical link between membrane proteins and the cytoskeletal network. |
| C-Terminal Regulatory Domain | Contains a serine-rich region and a hydrophobic tail that may regulate protein-protein interactions and localization. |
| Membrane Integrity | ANK1 variants may affect neuronal membrane stability, increasing vulnerability to amyloid-beta (Aβ) toxicity |
| Synaptic Dysfunction | Impaired ankyrin-1 function may contribute to synaptic loss in AD |
| Astrocyte Reactivity | Altered ANK1 expression in reactive astrocytes surrounding plaques |
| Associated Diseases | Alzheimer, Parkinson |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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