protein 2,462 words KG: ALPHASYNUCLEIN
Contents

Alpha-Synuclein (α-Syn)

🔬 Protein Info
Gene SymbolALPHASYNUCLEIN
AliasesALPHASYNUCLEIN
Chromosome4q21.31
α-Syn-140Full-length (140 aa) - predominant species in most tissues
α-Syn-126Exon 3 skipped (126 aa) - lacks central region, less aggregation-prone
α-Syn-98Exons 3 and 5 skipped (98 aa) - shortened, primarily in brain
α-Syn-115Alternative splice variant (115 aa) - rare isoform
KG Connections1 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (45)

Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Smartphone-Detected Motor Variability Correction
Score: 0.74
Phase-Separated Organelle Targeting
Score: 0.73
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Noradrenergic-Tau Propagation Blockade
Score: 0.71
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
Cross-Seeding Prevention Strategy
Score: 0.69
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64
Multi-Modal CRISPR Platform for Simultaneous Editing and Mon
Score: 0.63
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Ci
Score: 0.60
Glycosaminoglycan Template Disruption Approach
Score: 0.60
Netrin-1 Gradient Restoration
Score: 0.59
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
Astrocytic Connexin-43 Upregulation Enhances Neuroprotective
Score: 0.56
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
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Related Analyses (18)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (30)

TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45
Levodopa Response Determinants in PSP — Biomarker-Guided Pre
clinical · proposed · Score: 0.40
Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (1 edges)

biomarkers-alpha-synuclein describes ALPHASYNUCLEIN

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