protein 2,462 words KG: ALPHASYNUCLEIN
Contents

Alpha-Synuclein (α-Syn)

🔬 Protein Info
Gene SymbolALPHASYNUCLEIN
AliasesALPHASYNUCLEIN
Chromosome4q21.31
α-Syn-140Full-length (140 aa) - predominant species in most tissues
α-Syn-126Exon 3 skipped (126 aa) - lacks central region, less aggregation-prone
α-Syn-98Exons 3 and 5 skipped (98 aa) - shortened, primarily in brain
α-Syn-115Alternative splice variant (115 aa) - rare isoform
KG Connections1 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (45)

Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
APOE-Dependent Autophagy Restoration
Score: 0.88
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.98
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE-TREM2 Interaction Modulation
Score: 0.74
Aquaporin-4 Polarization Rescue
Score: 0.73
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Lysosomal Positioning Dynamics Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Glial Glycocalyx Remodeling Therapy
Score: 0.65
Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro
Score: 0.64
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
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Related Analyses (18)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (30)

TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45
Levodopa Response Determinants in PSP — Biomarker-Guided Pre
clinical · proposed · Score: 0.40
Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (1 edges)

biomarkers-alpha-synuclein describes ALPHASYNUCLEIN

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