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protein 1,532 words KG: 1433PROTEIN
Contents

14-3-3 Proteins — Adapter and Scaffold Proteins

🔬 Protein Info
Gene Symbol1433PROTEIN
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionmotor neurons and may contribute to selective vulnerability - TDP-43 pathology: 14-3-3 proteins interact with TDP-43 and may influence its aggrega
Subcellular Localization5. **Transcriptional regulation**: Interact with transcription factors
Molecular Weight28 kDa
Amphipathic groovebinds phosphorylated serine/threonine motifs
N-terminal dimerization domainforms functional dimers
C-terminal regulatory tailmodulates interactions
Associated Diseasesneurodegeneration
KG Connections1 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (7)

Synthetic Biology Approach: Designer Mitochondrial Export Sy
Score: 0.51Purinergic Signaling Polarization Control
Score: 0.71Mechanosensitive Ion Channel Reprogramming
Score: 0.70Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completedProtein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_inMitochondrial Fusion in Neurodegeneration
mechanism · Pages share 4 hypothesesDiffusion MRI (DTI) in Neurodegeneration
mechanism · Pages share 4 hypothesesSynthetic Lethality and PARP Inhibition in Neurodegener
mechanism · Pages share 4 hypothesesQuantum Biology and Coherent Energy Transfer in Neurode
mechanism · Pages share 4 hypotheses

Knowledge Graph (1 edges)

proteins-14-3-3-protein describes 1433PROTEIN

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