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biomarker 4,443 words KG: CSF
Contents

CSF Neurofilament Light Chain (NfL) in Neurodegeneration

🔬 Protein Info
Gene SymbolCSF
Heavy chain (NF-H)200-220 kDa, heavily phosphorylated
Medium chain (NF-M)160-170 kDa
Light chain (NfL)61-70 kDa, most soluble and abundant in CSF
α-internexinPresent in CNS neurons
PeripherinPeripheral nervous system specific
Associated DiseasesMULTIPLE SCLEROSIS
Known Drugs/CompoundsADUCANUMAB
KG Connections134 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Wikipedia

Related Hypotheses (38)

Elevated CSF/Serum Albumin Quotient Predicts Neurodegenerati
Score: 0.85CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion
Score: 0.81CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Wind
Score: 0.80Integrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2,
Score: 0.76TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming
Score: 0.75CSF YKL-40 as a Priming-Specific Chitinase Marker
Score: 0.71CSF/Plasma AQP4 Polarization Index as a Novel Biomarker of A
Score: 0.71CSF Soluble TREM2 Fragment Ratio as Priming State Indicator
Score: 0.69Matrix Metalloproteinase-9/TIMP-1 Ratio in CSF Identifies Pr
Score: 0.68CSF/Serum NfL Ratio Discriminates Active Transcytosis from P
Score: 0.67TREM2-Independent Microglial Activation via CSF1R
Score: 0.66IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral
Score: 0.65CSF Biomarker-Guided ABCA7 Therapeutic Dosing
Score: 0.62CSF ApoE- and clusterin-rich lipoprotein particles stabilize
Score: 0.61Temporal Decoupling of CSF p-tau217 Normalization from Amylo
Score: 0.59CSF p-tau217 Normalization Reflects Amyloid-Driven Tau Patho
Score: 0.59Residual Vascular Amyloid Prevents Complete CSF p-tau217 Nor
Score: 0.59Ganglioside-rich extracellular vesicles preserve alpha-synuc
Score: 0.58CSF1R Inhibition-Mediated Microglial Replacement as a State
Score: 0.58CSF p-tau217 Normalization Occurs Earlier Than Amyloid PET N
Score: 0.57
pg 1/2Next →

Knowledge Graph (12 edges)

neurodegeneration regulates CSF
TAU expressed_in CSF
CSF contains PROTEOME
CSF contains PD_ProS
Cryptic Hdgfl2 expressed_in CSF
CSF activates AQP4
NEUROFILAMENT LIGHT associated_with CSF
C9orf72 associated_with CSF
CSF inhibits MELANOMA
AMYLOID PET associated_with CSF

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