biomarker 4,443 words KG: CSF
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CSF Neurofilament Light Chain (NfL) in Neurodegeneration

🔬 Protein Info
Gene SymbolCSF
Heavy chain (NF-H)200-220 kDa, heavily phosphorylated
Medium chain (NF-M)160-170 kDa
Light chain (NfL)61-70 kDa, most soluble and abundant in CSF
α-internexinPresent in CNS neurons
PeripherinPeripheral nervous system specific
Associated DiseasesMULTIPLE SCLEROSIS
Known Drugs/CompoundsADUCANUMAB
KG Connections134 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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neurodegeneration regulates CSF
TAU expressed_in CSF
CSF contains PROTEOME
CSF contains PD_ProS
Cryptic Hdgfl2 expressed_in CSF
CSF activates AQP4
NEUROFILAMENT LIGHT associated_with CSF
C9orf72 associated_with CSF
CSF inhibits MELANOMA
AMYLOID PET associated_with CSF

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