mechanism 2,155 words KG: ent-gene-28e2cb01
Contents

TREM2+ Border-Associated Macrophages

🔬 Protein Info
Gene Symbolent-gene-28e2cb01
Dural macrophagesReside in the dural sinus areas, interact with venous blood
Arachnoid trabecular macrophagesFound within the arachnoid trabeculae
Pial macrophagesLie on the brain surface beneath the pia mater
Vascular smooth muscle cell-associatedAlong penetrating arterioles
Capillary-associatedNear the neurovascular unit
Venular macrophagesAlong post-capillary venules
Epithelial-associated macrophagesNear the choroid plexus epithelium
Meningeal macrophagesHigh TREM2 expression
Perivascular macrophagesModerate to high expression
Choroid plexus macrophagesVariable expression
Comparison to microgliaSimilar expression levels
KG Connections94 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (29)

HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Vocal Cord Neuroplasticity Stimulation
Score: 0.52
APOE-Dependent Autophagy Restoration
Score: 0.88
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
APOE Isoform Conversion Therapy
Score: 0.72
← Prevpg 2/2

Related Analyses (30)

Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · completed
Neuroinflammation and microglial priming in early AD
neurodegeneration · completed
Astrocyte Reactivity Subtypes in Neurodegeneration
neurodegeneration · archived
What are the optimal timing windows for TREM2 agonism vs ant
neurodegeneration · archived
Does SYK activation provide neuroprotection or exacerbate ne
neurodegeneration · archived

Related Experiments (30)

Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.45
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45
TREM2 KO amyloid pathology study
validation · completed · Score: 0.80
TREM2 KO amyloid pathology study
validation · completed · Score: 0.80

See Also (7)

sTREM2 (Soluble TREM2) - Microglial Biomarker
biomarker · Pages share 3 hypotheses
sTREM2 (Soluble TREM2) - Biomarker
biomarker · Pages share 3 hypotheses
al002-trem2-agonist-alzheimers
clinical_trial · Pages share 3 hypotheses
TREM2 Gene
gene · Pages share 3 hypotheses
TREM2 in Amyotrophic Lateral Sclerosis
mechanism · Pages share 3 hypotheses

Knowledge Graph (12 edges)

h-var-a8c6c6ea92 targets ent-gene-28e2cb01
ent-gene-28e2cb01 targeted_by h-var-a8c6c6ea92
ent-gene-28e2cb01 targeted_by h-b490c14bf6
h-dffb42d9de targets ent-gene-28e2cb01
ent-gene-28e2cb01 targeted_by h-dffb42d9de
h-var-223b8be521 targets ent-gene-28e2cb01
ent-gene-28e2cb01 targeted_by h-var-223b8be521
h-64e3588957 targets ent-gene-28e2cb01
ent-gene-28e2cb01 targeted_by h-64e3588957
h-var-42a172bc53 targets ent-gene-28e2cb01

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