| Gene Symbol | ent-gene-28e2cb01 |
| TDP-43 aggregates | The characteristic protein pathology in most ALS cases |
| SOD1 aggregates | Mutant SOD1 proteins that cause familial ALS |
| FUS aggregates | Ligand in FUS-linked ALS |
| Lipid debris | From degenerating motor neurons |
| Lipids and lipoproteins | TREM2 functions as a lipid sensor, binding oxidized lipids and lipoproteins that accumulate in neurodegeneration |
| Apolipoprotein E (ApoE) | Particularly the ApoE4 isoform, which is associated with increased ALS risk |
| Apoptotic cell remnants | Cellular debris from dying motor neurons |
| KG Connections | 94 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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