Contents

SORL1→APP Trafficking→Retromer Dysfunction→Aβ Accumulation→AD Causal Chain

🔬 Protein Info

Gene Symbol	ent-gene-ab756cfa
GWAS variants	Reduce SORL1 expression through altered transcription factor binding, enhancer activity, or splicing
Rare variants	Introduce amino acid changes in functional domains (VPS10P, LDLR, β-propeller) or create premature stop codons
KG Connections	3 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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