pathway 2,538 words KG: ent-gene-a6935314
Contents

SNCA→Alpha-synuclein→Parkinson's Disease Causal Chain

🔬 Protein Info
Gene Symbolent-gene-a6935314
Synaptic vesicle traffickingRegulates synaptic vesicle pool size and neurotransmitter release
Dopamine synthesisModulates tyrosine hydroxylase activity
Chaperone activityC-terminal region exhibits molecular chaperone function
Lipid bindingN-terminal domain binds synaptic vesicles
Antioxidant functionActs as molecular scavenger for ROS
ER-Golgi traffickingParticipates in vesicular transport
Rep1Microsatellite in promoter affects expression
SNPs in linkage disequilibriumMultiple risk haplotypes
SNCA triplicationCauses PARK4 with early-onset PD and dementia
SNCA duplicationCauses familial PD with incomplete penetrance
KG Connections8 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

WikiPathwaysKEGGReactome

Related Hypotheses (8)

Smartphone-Detected Motor Variability Correction
Score: 0.74
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70
Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro
Score: 0.64
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53

Related Analyses (30)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

Related Experiments (30)

PFF uptake in primary hippocampal neurons with inhibitors
exploratory · proposed · Score: 0.90
Longitudinal TLR2 reporter gene study in α-synuclein mice
validation · proposed · Score: 0.90
Dexamethasone treatment study in α-synuclein mice
validation · proposed · Score: 0.85
PFF clearance kinetics in Snca knockout mice
validation · proposed · Score: 0.80
TLR expression in α-synuclein overexpressing mice
validation · proposed · Score: 0.80

Knowledge Graph (8 edges)

h-fa757ac897 targets ent-gene-a6935314
ent-gene-a6935314 targeted_by h-fa757ac897
h-90b7b77f59 targets ent-gene-a6935314
ent-gene-a6935314 targeted_by h-90b7b77f59
ent-gene-a6935314 data_in benchmark_ot_ad_answer_key:SNCA
benchmark_ot_ad_answer_key:SNCA data_in ent-gene-a6935314
ent-gene-a6935314 participates_in_pathway R-HSA-9833482
ent-gene-a6935314 participates_in_pathway R-HSA-977225

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