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mechanism 2,167 words KG: lactate
Contents

Lactate Lactylation in Neurodegeneration

⚙ Mechanism Info
Namelactate
Key Genes/ProteinsCIRP, ERK, HADHA, LDHA, NLRP3, NUPR1
Related Diseasesacute lung injury, hepatic ischemia-reperfusion injury, sepsis-induced myocardial depression
Linked Hypotheses2 hypotheses

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🌐 Cross-references

Wikipedia

Related Hypotheses (148)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.89GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75APOE Isoform Expression Across Glial Subtypes
Score: 0.74SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65The Glial Ketone Metabolic Shunt Hypothesis
Score: 0.61Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Ci
Score: 0.60Microglia-Derived Extracellular Vesicle Engineering for Targ
Score: 0.48
← Prevpg 8/8

Related Analyses (30)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Selective Vulnerability of Dopaminergic Neurons — Mechanism
validation · proposed · Score: 0.40Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40

See Also (15)

Neuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypothesesChina Neurodegeneration Epidemiology
disease · Pages share 139 hypothesesSynaptic Biomarkers in Neurodegeneration
biomarker · Pages share 139 hypothesesBEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 139 hypothesesOlfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 139 hypotheses

Knowledge Graph (12 edges)

lactate activates NLRP3
lactate activates lactylation
ischemia-reperfusion injury activates lactate
lactate inhibits RARγ
lactate promotes CIRP
lactate promotes acute lung injury
lactate modulates RUBCN
lactate exacerbates hepatic ischemia-reperfusion injury
SIRT1 modulates lactate
lactate regulates HADHA

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