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mechanism 1,440 words KG: ent-gene-8c4c3123
Contents

BDNF Signaling Pathway in Neurodegeneration

🔬 Protein Info
Gene Symbolent-gene-8c4c3123
Mature BDNF/TrkBPromotes survival, plasticity, differentiation
Pro-BDNF/p75NTRPromotes apoptosis, synaptic pruning, developmental refinement
KG Connections10 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

Wikipedia

Related Hypotheses (153)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67TREM2-mediated microglial tau clearance enhancement
Score: 0.62Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61VCP-Mediated Autophagy Enhancement
Score: 0.59TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58Synaptic Vesicle Tau Capture Inhibition
Score: 0.58HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.48Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.36APOE-Dependent Autophagy Restoration
Score: 0.89
← Prevpg 8/8

Related Analyses (30)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

Lifestyle Intervention Mechanisms in Alzheimer's Disease
validation · proposed · Score: 0.40Sex Differences in Alzheimer's Disease — mechanisms and ther
clinical · proposed · Score: 0.40Biomarker-Guided Sequential Therapy Selection in Alzheimer's
clinical · proposed · Score: 0.40AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi
clinical · proposed · Score: 0.40Viral and Post-Infectious Mechanisms in ALS — Experiment Des
clinical · proposed · Score: 0.40

See Also (15)

Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 139 hypothesesChina Neurodegeneration Epidemiology
disease · Pages share 139 hypothesesNeuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypothesesSynaptic Biomarkers in Neurodegeneration
biomarker · Pages share 139 hypothesesOlfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 139 hypotheses

Knowledge Graph (10 edges)

biomarkers-bdnf-brain-derived-neurotrophic-factor describes ent-gene-8c4c3123
ent-gene-8c4c3123 data_in benchmark_ot_ad_answer_key:BDNF
benchmark_ot_ad_answer_key:BDNF data_in ent-gene-8c4c3123
15518235 has central roles in ent-gene-8c4c3123
15518235 appears essential to ent-gene-8c4c3123
15518235 modification of ent-gene-8c4c3123
21768599 may mediate ent-gene-8c4c3123
41104344 elevated ent-gene-8c4c3123
30642045 plays no role in ent-gene-8c4c3123
40133606 plays a role in ent-gene-8c4c3123

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