protein

MADD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MADD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

0Hypotheses

0Analyses

1Outgoing

2Incoming

0Experiments

0Debates

Summary

MADD (MAP3K14 Associated Death Domain Protein) - a signaling adaptor involved in apoptosis, NF-κB signaling, and neurodegenerative disease

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🔬 Protein Info

Gene Symbol	MADD
Aliases	MAP3K14 Associated Death Domain Protein
Function	MADD is highly expressed in the central nervous system, particularly in hippocampal neurons, cortical pyramidal cells, and dopaminergic neurons of the substantia nigra.
Molecular Weight	95 kDa
Amino Acids	836 aa
Pathways	NF-κB signaling
GeneCards	MADD
Human Protein Atlas	MADD
KG Connections	3 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

MADD Protein

protein · 1331 words

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Pathway Diagram

flowchart TD
    N0["MADD"]
    N1["NCL"]
    N1 -->|"regulates"| N0
    N2["lactylation"]
    N2 -->|"regulates"| N0
    N3["ERK"]
    N0 -->|"upstream of"| N3

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 protein
    class N1 protein
    class N2 process
    class N3 protein

Outgoing (1)

Target	Relation	Type	Str
ERK	upstream_of	protein	0.90

Incoming (2)

Source	Relation	Type	Str
NCL	regulates	protein	0.95
lactylation	regulates	process	0.92

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MADD in their description or question text

No additional research found