| Gene Symbol | KCNK10 |
| Full Name | Potassium Two Pore Domain Channel Subfamily K Member 10 |
| Chromosome | 3p24.3 |
| Function | The KCNK10 gene encodes the potassium two pore domain channel subfamily K member 10, also known as TASK-3 (TWIK-related acid-sensitive potassium channel 3). |
| Primary Expression | substantia nigra dopaminergic neurons - TASK-3 currents protect against MPTP-induced parkinsonism in mice - May modulate neuronal vulnerability to oxi |
| Molecular Weight | 56 kDa |
| Pathways | Cellular Excitability, Potassium Ion Transport, Temperature Gating |
| UniProt ID | [Q9NPC6](https://www.uniprot.org/uniprot/Q9NPC6) |
| Ensembl ID | ENSG00000100417 |
| GeneCards | KCNK10 |
| Human Protein Atlas | KCNK10 |
| pH sensitivity | Activated by extracellular acidic pH |
| Volatile anesthetics | Inhibited by halothane and isoflurane |
| Hypoxia response | Activated by low oxygen conditions |
| Mechanical sensitivity | Responds to membrane stretch[@meadows2000] |
| Associated Diseases | neurodegeneration |
| Interactions | KCNK2, NEURODEGENERATION, TREK-1 |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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