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Institution: NIH Drug Repurposing Program for Neurodegenerative Diseases
institution
3,160 words
KG: NIH Drug Repurposing Program for Neurodegenerative Diseases
Contents
NIH Drug Repurposing Program for Neurodegenerative Diseases
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Knowledge Graph
Agent Input
Related Hypotheses (16)
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.98
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Aquaporin-4 Polarization Rescue
Score: 0.73
Adenosine-Astrocyte Metabolic Reset
Score: 0.73
Microglial Purinergic Reprogramming
Score: 0.70
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
APOE-Dependent Autophagy Restoration
Score: 0.88
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58
Related Analyses (11)
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Show 6 more
Related Experiments (3)
Circadian-Vascular-Metabolic Syndrome (CVMS) Intervention Tr
clinical · proposed · Score: 0.40
Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecu
clinical · completed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Knowledge Graph (1 edges)
NIH Drug Repurposing Program for Neurodegenerative Diseases
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NIH Drug Repurposing Program for Neurodegenerative Diseases
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