| Gene Symbol | ent-gene-c17329a1 |
| ACSL4 is essential for ferroptosis | Cells lacking ACSL4 are resistant to ferroptosis even when GPX4 is inhibited[@doll2017] |
| Neuronal vulnerability | Certain neuronal populations (e.g., cortical neurons, dopaminergic neurons) show heightened sensitivity to ferroptosis |
| Lipid composition matters | ACSL4 preferentially produces phosphatidylethanolamines with arachidonoyl/ adrenoyl chains that undergo peroxidation |
| Therapeutic window | Partial inhibition may be sufficient to provide neuroprotection without disrupting essential lipid metabolism |
| Combination potential | Can synergize with GPX4 activators, ferrostatin analogs, and iron chelators |
| With GPX4 activators | Dual mechanism (lipid + hydroperoxide prevention) |
| With ferrostatin analogs | Enhanced antioxidant effect |
| With iron chelators | Block iron-dependent peroxidation |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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