| Gene Symbol | SP3 |
| Full Name | Specificity Protein 3 |
| Protein Type | Transcription Factor |
| Function | SP3 is a sequence-specific transcription factor that binds to GC-rich promoter elements (GC boxes) and regulates gene expression. |
| Primary Expression | all CA regions and dentate gyrus - Cerebellum: Present in Purkinje cells and granule cells - Substantia Nigra: Detected in dopaminergic neuron |
| Ensembl ID | ENSG00000172845 |
| GeneCards | SP3 |
| Human Protein Atlas | SP3 |
| Transactivation Domains | N-terminal regions required for transcriptional activation |
| Zinc Finger Domain | C-terminal DNA-binding domain with three C2H2-type zinc fingers |
| Repressor Domain | Contains domains that can recruit co-repressors |
| Amyloid Regulation | SP3 regulates APP (Amyloid Precursor Protein) expression |
| [Tau](/proteins/tau) Pathology | Involved in regulation of tau-associated genes |
| Neuroinflammation | Controls inflammatory gene expression in microglia |
| Associated Diseases | neurodegeneration |
| Interactions | ATP2A3, CANCER, DNA |
| KG Connections | 19 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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