| Gene Symbol | SACS |
| Function | encodes a very large multidomain protein involved in protein quality control and mitochondrial dynamics. |
| Molecular Weight | 520 kDa |
| Amino Acids | 579 aa |
| Ensembl ID | ENSG00000151835 |
| GeneCards | SACS |
| Human Protein Atlas | SACS |
| Protein folding | SRR domains assist in folding/refolding of client proteins, analogous to Hsp90 |
| Protein quality control | Participates in ubiquitin-proteasome-mediated degradation of misfolded substrates |
| DnaJ domain | The J-domain recruits Hsp70 chaperones to facilitate substrate processing |
| HEPN domain | C-terminal higher eukaryotes and prokaryotes nucleotide-binding domain with potential nuclease function |
| Mitochondrial fission | Promotes DRP1-mediated mitochondrial fission |
| Network morphology | Loss of sacsin causes hyperfused, elongated mitochondrial networks |
| Mitophagy | Required for efficient clearance of damaged mitochondria |
| Respiratory chain | Sacsin-deficient cells show impaired oxidative phosphorylation |
| Associated Diseases | neurodegeneration |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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