gene 932 words KG: MTCH2
Contents

MTCH2 — Mitochondrial Carrier Homolog 2

🧬 Gene Info
Gene SymbolMTCH2
Full NameMitochondrial Carrier Homolog 2
Chromosome11p15.4
FunctionMTCH2 is a phylogenetically conserved protein that localizes to the outer mitochondrial membrane
Molecular Weight35 kDa
Amino Acids303 aa
PathwaysApoptosis, Stem Cell
UniProt ID[Q9Y6C9](https://www.uniprot.org/uniprot/Q9Y6C9)
Ensembl IDENSG00000135249
OMIM614215
GeneCardsMTCH2
Human Protein AtlasMTCH2
Serves as insertaseFunctions as a mitochondrial outer membrane insertase for proteins [@gonzalez2025]
Regulates mitophagyControls mitophagy initiation and mitochondrial quality control [@yang2025]
Interacts with Bcl-2 familyAssociates with pro-apoptotic and anti-apoptotic proteins
Associated Diseasesneurodegeneration
InteractionsSelH
KG Connections11 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (14)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (10)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (6)

Neurodegeneration
disease · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: regulates
Mitochondria
entity · KG edge: regulates
BID — BH3 Interacting Domain Death Agonist
gene · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: regulates

Knowledge Graph (11 edges)

MTCH2 binds tBID
tBID binds MTCH2
Cucurbitacin B binds MTCH2
SelH interacts_with MTCH2
MTCH2 regulates BID
MTCH2 regulates APOPTOSIS
MTCH2 regulates BCL-2
MTCH2 regulates MITOCHONDRIA
MTCH2 regulates Als
MTCH2 regulates Apoptosis

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