| Gene Symbol | KDM4B |
| Full Name | Lysine Demethylase 4B |
| Chromosome | 19p13.3 |
| Function | encodes a Jumonji C (JmjC) domain-containing histone demethylase that catalyzes the removal of di- and trimethyl groups from histone H3 at lysines 9 and 36 (H3K9me2/3 and H3K36me2/3). |
| Amino Acids | 096 aa |
| UniProt ID | [O94953](https://www.uniprot.org/uniprot/O94953) |
| Ensembl ID | ENSG00000127663 |
| GeneCards | KDM4B |
| Human Protein Atlas | KDM4B |
| JmjN domain | The N-terminal Jumonji N domain (~80 amino acids) is required for catalytic activity and protein stability. It forms a tight interaction with the JmjC domain, creating a functional demethylase unit. |
| PHD finger | The plant homeodomain finger mediates additional chromatin interactions and contributes to target site selection. |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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