| Gene Symbol | Dual Specificity Phosphatase 8 |
| Chromosome | 22q12.2 |
| Protein Type | Phosphatase |
| Function | DUSP8 encodes a dual-specificity phosphatase that belongs to the MAPK phosphatase (MKP) family. |
| Amino Acids | 170 aa |
| Pathways | MAPK |
| UniProt ID | Q8WUA5 |
| NCBI Gene ID | 1853 |
| Ensembl ID | ENSG00000134548 |
| OMIM | 607769 |
| JNK (c-Jun N-terminal Kinase) | Mediates stress-induced apoptosis in neurons |
| p38 MAPK | Regulates inflammatory responses and neuronal death pathways |
| Brain | High expression in cortex, hippocampus, basal ganglia |
| Cerebral Cortex | Both pyramidal neurons and interneurons |
| Hippocampus | CA1-CA3 regions and dentate gyrus |
| Associated Diseases | Breast Cancer, Colorectal Cancer, Diabetic Kidney Disease, Trastuzumab Resistance |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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