gene 1,339 words KG: DAB2
Contents

DAB2 — Disabled Clathrin Adaptor Protein

🧬 Gene Info
Gene SymbolDAB2
Full NameDisabled Clathrin Adaptor Protein
Chromosome5p13.2
Protein TypeAdaptor Protein
Functionencodes a clathrin-associated adaptor protein that plays critical roles in endocytosis, signal transduction, and protein homeostasis.
Amino Acids830 aa
Exons22
PathwaysNotch
UniProt ID[P98073](https://www.uniprot.org/uniprot/P98073)
Ensembl IDENSG00000153046
GeneCardsDAB2
Human Protein AtlasDAB2
DAB2 isoform A (p96)Full-length protein (830 aa)
DAB2 isoform B (p67)Truncated isoform lacking N-terminal sequences
LDL Receptor FamilyLDLR, LRP1, LRP2
Associated DiseasesAlzheimer's Disease, Parkinson's Disease
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (5)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
APOE Isoform Expression Across Glial Subtypes
Score: 0.74

Related Analyses (2)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
AGGF1 Gene - Angiogenic Factor
gene · KG edge: upregulates
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 3 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 3 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

Knowledge Graph (3 edges)

AGGF1 upregulates DAB2
DAB2 data_in benchmark_ot_ad_answer_key:DAB2
benchmark_ot_ad_answer_key:DAB2 data_in DAB2

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.