| Gene Symbol | CERK |
| Chromosome | 22q13.31 |
| Function | Substrate specificity: Prefers ceramide with C16:0, C18:0, C24:0, C24:1 acyl chains |
| Primary Expression | neurons and glia throughout the brain, with highest expression in hippocampus, [cortex](/brain-regi |
| Amino Acids | 538 aa |
| Exons | 11 |
| Pathways | PI3K |
| Ensembl ID | ENSG00000100324 |
| GeneCards | CERK |
| Human Protein Atlas | CERK |
| PH domain | Pleckstrin homology domain for membrane localization |
| Diacylglycerol kinase domain | Catalytic domain with ATP-binding site |
| C1 domain | Lipid-binding cysteine-rich region |
| Calcium/calmodulin regulation | Calcium-dependent activation |
| Microglial activation | C1P promotes pro-inflammatory phenotype |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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